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What is Zoloft?
Zoloft is an antidepressant that is in the group of SSRI (selective serotonin reuptake inhibitor). The medicine is prescribed as an oral drug for a therapy course that presupposes a dosing schedule of daily intakes that cannot be interrupted. The medicine affects the chemicals in the patient’s brain helping to normalize their balance and prevent depression from aggravating. The therapy is aimed at managing and/or full recovery from depressive states and other psychiatric disorders.
Zoloft is an oral antidepressant, a powerful specific inhibitor of the reuptake of serotonin (5-HT) in neurons. The medicine produces a little effect on the reuptake of norepinephrine and dopamine. At therapeutic doses, the agent blocks the uptake of serotonin into human platelets. The drug has no stimulating, sedative or anticholinergic action. Due to the selective inhibition of 5-HT uptake, sertraline (the active medicinal ingredient of the drug) does not enhance adrenergic activity. the agent has no affinity for muscarinic choline receptor, serotonin, dopamine, histamine, GABA-, benzodiazepine, and adrenoceptors.
Sertraline does not cause drug dependence does not cause weight gain during chronic administration. In contrast to tricyclic antidepressants in treating depression or obsessive-compulsive disorder, the drug does not increase body weight. The initial effect develops within 7 days, full – after 2 to 4 weeks of the therapy.
How to use Zoloft?
Zoloft is a drug of peroral administration by 50mg 1 time a day in the morning or evening, with or without food. In the absence of the anticipated effect, your prescriber may gradually (over the course of several weeks) increase the dose to 200mg / day (50mg / week). Some clinicians recommend appointing the first dose of 25mg / day for 1-2 days. For panic disorder: the initial dose is 25mg / day increasing to 50mg / day for 1 week. Within the course of a long-term maintenance therapy, the drug is prescribed in the lowest effective dose, which subsequent adjustment depending on the response. In patients with OCD: children and adolescents of 13-17 years the initial dose is 50mg / day; in children of 6-12 years of the initial dose is 25mg / day, with a subsequent increase within 1 week to 50mg / day. With the poor response, the dose can be increased stepwise to 50mg / day to 200mg / day, with an interval of at least 1 week. In elderly patients, the initial dose is 25mg / day (morning or evening) followed by a gradual increase.
In the period of the treatment, the behavior of patients with depression (risk of suicide attempts) should be monitored closely until a significant improvement as a result of the treatment. Zoloft is administered no earlier than 14 days after discontinuation of MAO inhibitors. Women of childbearing age should use appropriate methods of contraception during the treatment. During the period of treatment, you must be careful when driving and with the occupation of other potentially hazardous activities that require your full attention and psychomotor speed reactions.