Sildenafil Citrate as an Element of Viagra Super Force

Sildenafil citrate is prescribed to men with erectile dysfunction. This substance is the basis of Viagra Super Force. That is the agent for the treatment of erectile dysfunction, which restores impaired erectile function and provides a natural response to sexual stimulation. This agent is not the only substance in Viagra composition. This chemical compound containing nitrogen, oxygen, hydrogen, carbon, and sulfur. It is the main ingredient of the drug. Viagra tablets also contain magnesium stearate, croscarmellose sodium, calcium hydrogen phosphate anhydrous and microcrystalline cellulose.
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The History of Sildenafil

This substance was synthesized by a group of chemists working at Pfizer’s Sandwich department (Kent, UK). Originally it was supposed to be used to treat hypertension (high blood pressure), angina pectoris (a symptom of coronary artery disease).

The first clinical researchers in the hospital Swansea showed very different properties of Viagra active ingredient – treatment of angina proved totally ineffective but contributed to the emergence of an erection in 80% of cases.

Pfizer Company has decided to abandon further tests, associated with angina therapy. In 1996, Sildenafil was patented as a means of improving potency. US Agency FDA has approved the citrate in 1998 – the world’s first drug for erectile dysfunction treatment appeared on the market the same year. Gradually, Viagra became more popular. The peak of the drug popularity was reached in 2008 when they sold these tablets for 1.934 million dollars (only in the United States). Terret Nicholas, David Brown, Andrew Bel are considered the developers of this substance.

Mechanism of Action

Sildenafil relates to a selective inhibitor of phosphodiesterase type 5. The substance dilates blood vessels in the sexual organs and increases the blood flow to them, when enters the body. The result is a continuous erection.

Efficiency

The component of Viagra helps in 90% of cases of erectile dysfunction. Sildenafil is safe for many patients, but we advise to consult your doctor before the use.

The efficiency of the preparation was evaluated using the data of the global erections’ diary, the international index of erectile function (a validated questionnaire on the status of sexual function), and partner survey.

The effectiveness of this agent, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated and confirmed in long-term studies.

Analysis of the international index of erectile function showed that the substance does not only improves an erection but also improves the quality of orgasm, helps achieve satisfaction from a sexual intercourse.

According to the summarized reported data, a sufficient number of patients improved their erection after treatment with Sildenafil:

• 59% of patients with diabetes;
• 43% of patients who underwent radical prostatectomy;
• 83% of patients with spinal cord injuries.

Special Instructions

1. Before taking this PDE5 inhibitor for the treatment of erectile dysfunction the doctor should conduct a survey of the cardiovascular system;
2. Patients with anatomical deformation of the penis (such as angulation, cavernous fibrosis or Peyronie’s disease), people with diseases that predispose to the development of priapism (such as sickle cell anemia, multiple myeloma or leukemia) should take the drug with caution;
3. Patients for whom sexual activity is undesirable, patients with a tendency to bleeding, gastric ulcer and duodenal ulcer in the acute phase, patients with hereditary retinitis pigmentosa are not advised to take this drug;
4. Sildenafil is not advised under the age of 18;
5. This agent doesn’t affect the ability to drive vehicles and manage mechanisms.

Learn what else is necessary to pay attention to while taking Sildenafil at medlineplus.gov.

Can Women Take Sildenafil?

Everyone knows that the female and male genitalia are getting excited on a similar principle. That is why there are often attempts to use Sildenafil to increase female libido. Many women have noted a significant or slight increase in sexual desire and pleasant sensations during orgasm.

The official instruction indicates that natural Sildenafil citrate is not meant for treatment of women.

Apparently, it just means that the impact of the active substance on the female body was not specifically examined. We need more research to understand exactly whether the drug helps the fair sex or not.

How long does Sildenafil take to work?

Sildenafil citrate takes effect within 15-25 minutes.

The maximum blood concentration of Sildenafil is observed 1.5-2.5 hours later. The validity period is 4 hours. During this time, you can engage in sexual activity even if there is a serious disruption of the functioning of the reproductive system. There is evidence showing that sometimes PDE5 inhibitor Sildenafil operates up to 6 hours. This figure is quite strongly influenced by the fat content and density of the food. High-calorie foods with a high-fat content (pizzas, burgers and so on.) can not only delay the effect but also adversely affect the efficiency of the drug.

Contraindications

Sildenafil citrate online can’t be taken in the presence of a number of diseases:

• coronary artery disease;
• heart problems or heart rate;
• heart failure, susceptibility to heart attacks;
• heart attack or stroke;
• hypotension or hypertension;
• liver or kidney disease;
• disorders associated with blood cells (sickle cell anemia, multiple myeloma, etc.);
• blood clotting disorders (hemophilia, etc.);
• stomach ulcer;
• retinitis pigmentosa;
• deformity of the penis.

Sildenafil may interact with other certain medicines. That is why this substance cannot be combined with the drugs from the following groups:

• nitrate-containing drugs;
• guanylate cyclase stimulants;
• alpha-blockers;
• certain antibiotics and antifungals;
• HIV protease inhibitors;
• other medicines to treat impotence.

Sometimes men have an allergy to Canadian Sildenafil. In this case, you need to stop taking the medication. Be sure to inform your doctor that you take Sildenafil.

Side Effects

Common side effects of Sildenafil:

• a common headache;
• temporary blurred vision;
• upset stomach.

Rare adverse reactions:

• bladder pain;
• dizziness;
• pain during urination;
• pain in the back or lower abdomen;
• chest pain;
• eye bleeding;
• sleepiness;
• reddening of the skin;
• dry mouth.

Online pharmacy Sildenafil may reduce the blood flow in the optic nerve that leads to a temporary loss of vision. This effect was observed just in a few people suffering from diabetes, hypertension, high cholesterol level. It is still unknown whether Sildenafil causes temporary loss of vision.