Top 3 Synthetic Drugs for Erectile Dysfunction
In recent years, world pharmaceutical market obtained a huge number of different products that improve male sexual power. This includes herbal medicines – herbal or dietary supplements (biologically active additives), such as Yohimbine, Yohimbe Plus Golden Horse, homeopathic medicines such as Impaza and many others. And also chemically synthesized drugs: Viagra, Cialis, Levitra, drugs of prostaglandin E-1, phentolamine and others.
Each of the drugs has an absolute right to exist because the number and variety of products allow doctors to find a more effective treatment for erectile dysfunction, depending on reasons that caused it.
Let us try to deal with this variety of drugs used for erectile dysfunction treatment (impotence). In this article, My Canadian Pharmacy will focus on pills, synthesized synthetically.
Viagra was first introduced into the pharmaceutical market in 1992. International name: «Sildenafil» (sildenafil citrate). It was the first representative of a new group of drugs called phosphodiesterase inhibitors of type 5.
The drug widens penis blood vessels in case of adequate sexual stimulation. As a result blood flow to penis increases, which contributes to normal erection occurrence.
Viagra active ingredient is sildenafil. One pill contains 25 mg, 50 mg or 100 mg of sildenafil. The composition also includes the following inactive ingredients:
- microcrystalline cellulose;
- calcium hydrogen phosphate;
- croscarmellose sodium;
- magnesium stearate;
- titanium dioxide (U171);
- indigo carmine aluminum lake (E132).
Viagra is used to treat men with erectile dysfunction, also called impotence. In this condition, a normal erection necessary for sexual intercourse does not occur. This drug works only in response to natural sexual stimulation and has no effect on reproductive function.
Viagra is contraindicated in cases when:
- previous allergic reactions to the drug (an allergic reaction can occur as rash, itching, facial or labial edema, dyspnea, anaphylactic shock). In case of these symptoms, consult your doctor.
- taking medicines containing nitrates or nitric oxide donators for cardiac angina treatment. If you use such drugs, you are forbidden to take this remedy!
If you suffer from any of the following conditions, consult your doctor before taking Viagra.
- sickle-cell anemia (change of red blood cells);
- leukocytic sarcoma (blood cancer);
- multiple myeloma (bone marrow cancer);
- penis diseases or deformity;
- previous or present treatment with drugs causing erectile dysfunction (special precautions may be necessary in this case situation);
- a rare eye disease called pigmented retinitis;
- stomach and duodenal ulcer;
- diseases accompanied by hemorrhages (e.g., hemophilia), in the presence of such diseases Viagra can cause undesirable effects;
- sildenafil should not be used in combination with other agents intended for erectile dysfunction treatment;
- the drug should not be taken by adolescence under 18 years;
- used by elderly people and patients with renal or hepatic diseases;
- necessary to state interaction with other drugs (make sure to inform your doctor about all medications you are taking, because the drug can interact with certain medications).
The doctor will decide which dosage you should take. For most men, it is 50 mg but depending on efficacy and tolerability, dosage can be increased to either 100 mg or decreased to 25 mg.
Do not take dosages greater than it was recommended by your doctor. Do not take more than one pill a day. If you have taken more pills than you have been advised immediately seek medical help.
Viagra should be taken about 30 min – 1 hour before sexual intercourse. Swallow the pill whole with a small amount of water. The drug contributes to an erection only in case of adequate sexual stimulation or excitement. Spontaneous erection without sexual stimulation won’t occur.
The effect comes at different periods at different people, but it is usually from 30 minutes to 1 hour after administration and lasts for 4 – 6 hours. After a heavy meal, the effect may come later. Drinking alcohol can cause temporary erectile dysfunction and increased side effects, so it is not recommended to drink alcoholic drinks with Viagra.
If the drug does not cause an erection or persists not long enough to complete sexual intercourse, you should consult your doctor.
Like most other drugs, Viagra can cause some adverse reactions (side effects). Most common side effects are headaches and flushes. Less common – digestive disorders, dizziness, nose stuffiness and vision disorders (change of objects color, the increased light brightness or blurred vision). If you suffer from any of these side effects, consult your doctor and.
Cialis (tadalafil) is a ED drug developed by the pharmaceutical company Eli Lilly and YCOS corporation.
Mechanism of action of this drug s is the same and provided by inhibiting phosphodiesterase type 5 (PDE-5), which metabolizes 3′, 5′ – cyclic guanosine monophosphate (GMP), responsible for penis erection. Men with ED have GMP level insufficient to provide a full erection. In order to maintain necessary GMP level common method was used, which consists in inhibition of the enzyme that resolves GMP.
Data on these drugs pharmacogenetics evidence in favor of Cialis. Thus, Viagra half-life period is 3 – 5 hours (depending on dosage) and Cialis – 17.5 h; Viagra lasting period is 4-6 hours, Cialis – 36 hours.
Side effects of this drug: dizziness, headaches, diarrhea, sickness, flu-like symptoms (nasal stuffiness), blood rushes to head, headaches, back pains, abdominal pains, joint pains, color vision disorders.
Indications and contraindications are the same. The drug is prescribed only by a doctor.
At the moment pharmaceutical market, a new drug Levitra (vardenafil) entered. At II phase of clinical trials, vardenafil showed a positive effect on 80% of men, regardless of age.
At annual meeting «Sexual Medicine Society of North America» «Bayer» company first presented data on III phase of clinical trial, according to which drug effectiveness has reached 85%. It is higher than that of Viagra – company «Pfizer» «blockbuster». Sildenafil is effective in 82% of men taking it. Trials of generic Levitra were attended by 736 men over 18 years old suffering from erectile dysfunction (slight or short-term erections). «Bayer» and the largest European pharmaceutical company «GlaxoSmithKline Plc.» are already realizing joint promotion of drug into the global market.
Levitra is challenging Viagra, the first pill to treat impotence, appeared on market in 1992. Perhaps this drug will compete with Cialis, developed for impotence treatment by “Eli Lilly & Co”. All three drugs act by blocking phosphodiesterase type 5 enzyme and all three drugs require sexual stimulation. However, previous clinical trials have shown that Cialis and Levitra drugs work faster and have fewer side effects than Viagra.
My Canadian Pharmacy has a wide range of medications for ED treatment at lowest prices. Buy Viagra, Cialis and Levitra online on our website. Making orders is very simple and you can make sure it is completely safe and confidential. Our highly qualified staff is glad to consult you on any question you might have about drugs or our service.