History of Viagra Creation

Viagra (Sildenafil citrate) is the third great achievement of scientists of the twentieth century after penicillin and x-rays. It has an unusual history of creation, which starts in 1992. Viagra is the world’s first oral tableted pharmaceutical agent that was found to be effective for the majority of men suffering from erectile disorders. The researchers, who brought joy to thousands of men, in 1998 were awarded the Nobel Prize.

Side Effect that Changed Millions of Men’s Lives

One of the main conditions for harmonious and long relationships between man and woman – partner’s physical and sexual health. However, daily troubles, conflicts at work, stressful situations, desire to succeed in life often affect both physical and sexual well-being of men. And to unpleasant situations at work and everyday stress problems in the intimate sphere are gradually added, which sometimes descend up with diagnosis – «erectile dysfunction». In this context, it should be remembered that problem of erectile dysfunction can be eliminated by using modern effective drugs with good safety profile.

The term «erectile dysfunction» was proposed in 1988 by US National Institutes of Health and replaced outdated «impotence». Erectile dysfunction is defined as the inability to achieve and/or maintain an erection sufficient for sexual intercourse. In the structure of sexual disorders, this pathology occupies leading position in frequency of occurrence and social significance.
Viagra unusual history of creation
Revolutionary event in erectile dysfunction treatment was an appearance in 1992 of sildenafil citrate drug, which became known under the brand name Viagra.

History of Viagra Discovery: Interesting Facts

1. Viagra became world famous due to a side effect. In the 90s of the last century, scientists working at American company «Pfizer», engaged in the invention of a new drug that was supposed to relieve chest pains in cardiac angina. The results of clinical trials of sildenafil, conducted in 1992, involving several thousand patients with ischemic heart disease, have disappointed developers – Peter Dunn and A. Wood (Andrew Bell, David Brown, and Nicholas Terrett were those who invented Viagra (Sildenafil citrate) in the first place); it was found that active ingredient – sildenafil, had no proper effect on heart functioning. At the same time all men, who participated in trials, with enthusiasm talked about pronounced side effect associated with improved potency. When most of the participants have flatly refused to return useless for heart pills, and one of them even tried to get into the lab to replenish his stock, company’s managers realized that they found a «gold mine».

New miracle cure has been given a name consisting of words composition: Vigor (which means «power», «strength») and Niagara (Niagara Falls), which is recognized as the most powerful waterfall in North America.

Since 1993 there were conducted long and complex researches, the purpose of which was to confirm the unusual properties of Viagra. As a result, they proved not only high efficiency but also the safety of pills to deal with male erectile dysfunction. As a result, United States Food and Drug Administration has authorized the release of the drug.

2. Later sildenafil has also shown efficacy in pulmonary hypertension treatment.

3. In 1998 Viagra was mentioned in connection with Nobel Prize award in Physiology and Medicine.

4. This drugwon Galen prize in 1999 – in the Netherlands, in 2000 – in France and the UK, in 2001 – in Canada.

5. In 2001 «Pfizer» company was awarded Queens Award for Enterprise (Great Britain) for its discovery and development;

6. In 2003 Viagra won in «The most vivid brand of pharmaceutical market of the Ukraine» nomination.

Sildenafil is a selective inhibitor of specific phosphodiesterase type 5 (PDE-5) cyclic guanosine monophosphate in cavernous bodies, where PDE-5 is responsible for the breakdown of cyclic guanosine monophosphate (cGMP). Blockade of this enzyme leads to cGMP accumulation, which causes relaxation of smooth muscle cells, allowing erection.

Today sildenafil is the gold standard in erectile dysfunction treatment. This is primarily due to its high efficiency, as well as an oral non-invasive form of sildenafil.

It should be noted that drug effect, i. e. onset of erection, begins in 14 – 20 minutes after administration and duration of the action in most men is 12 hours. It remains effective 4 years after a regular reception, so, more than 94% patients who participated in a clinical study of Viagra drug effectiveness, after 4 years of regular admission reported that they were satisfied with treatment results and significantly increased the level of sexual activity.

Viagra unusual history of creationWith Viagra, men can have sex more often and longer. Viagra increases erection duration in men with erectile dysfunction without changing sperm characteristics and has a positive effect on erection restoration after ejaculation in presence of continuous sexual excitement. It is worth noting that Viagra has favorable safety profile. Thus, the incidence of acute cardiovascular diseases in patients with erectile dysfunction is not higher than that in general population.