Viagra in the Treatment of Pulmonary Hypertension

Scientist argues whether Viagra (Sildenafil citrate) for pulmonary hypertension treatment can be used as effectively as for erectile dysfunction. Viagra is now being considered as a means for cardiac diseases treatment. However, new research on animals conducted by Johns Hopkins University (Baltimore, MD, USA), have shown that this drug can have different effects on the male and female body, and what side effects of Sildenafil for pulmonary hypertension can appear.

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How Can Sildenafil Help in Pulmonary Hypertension?

Pulmonary arterial hypertension is a rare disease from which people «fade away» in about three years.

Doctors are still arguing about causes that provoke PAH. According to one version, this dangerous disease can be caused oral contraceptives, another – even wrong weight loss. Pulmonary hypertension can occur in people with cardiac disease, thyroid gland disorders and liver diseases, also PAH have been found in people with HIV.

At pulmonary hypertension, patients strength is on the wane: reduced physical endurance, dyspnea, cough, cardiac angina, fainting, feet swelling. Eventually there comes cardiac insufficiency. If not start treatment, a person can die within three or four years.

Sildenafil contributes to vasodilation and increased blood flow. In case of patients with erectile dysfunction (impotence) it stimulates blood flow to penis.

Drug effect is similar to action of such drugs as nitroglycerine, which increases blood flow to diseased heart muscle, so now active researches on using Sildenafil for pulmonary arterial hypertension are conducted, trying to determine whether Canadian Viagra realy can be used for this disease treatment and what Sildenafil dose for pulmonary hypertension should be used in this case. As soon as results will be obtained, it will be possible to work out the detailed guidelines, which will help people to properly and correctly use the drug, knowing maximum dose of Sildenafil for pulmonary hypertension.

Cost of Sildenafil for pulmonary hypertension treatment may be also different from ED treatment, and there are opinions that there may be free Viagra for pulmonary hypertension.

Currently, cardiac insufficiency is one of the most common causes of hospitalization of patients with cardiovascular diseases. Even moderate damage to heart muscle cells due to heart attack, high blood pressure can cause large-scale disturbances in cardiac performance and reduce blood supply to the body effectiveness. Applicable, in this case, are such drugs as beta-blockers and ACE inhibitors, which help to improve contractility of heart muscle, but, according to experts, do not fully solve problem of underlying pathology.

Viagra for Heart Remodeling

American scientists focused on substance responsible for «useful biochemical cascade» that relieves symptoms of hypertension and other stress factors. Strategic supply of this substance called cyclic guanosine monophosphate (cGMP) in heart cells is generally maintained at a constant level, but may be depleted due to certain diseases.

Sildenafil increases cGMP level, that is, it actually struggles with heart disease.

During experiment scientists-cardiologists caused in mice classical symptoms of cardiac insufficiency (transverse aortic constriction by surgery and increase internal pressure in heart), and then introduced sildenafil. As a result of its introduction there was a persistent increase in cGMP level, as well as cardiac remodeling process caused by cardiac insufficiency was blocked and reversed (structural changes taking place under pathological factors influence and infringing heart function).

It should be noted that similar results were obtained in several other studies on animals, which opens up broad prospects for using sildenafil as a drug for cardiac insufficiency in humans.