Tadalafil as a Basic Ingredient of Cialis Professional
Tadalafil is an active component of not only Cialis Professional but also a variety of other generics, which makes them accessible for people with different income levels. Generics with this substance have an international non-proprietary name or proprietary but modified. They are manufactured mainly in India.
[ithshop code=”cialispro” tpl=”short” page_id=”262″ dummy=”txt”]
Description of Tadalafil
Tadalafil is a solid crystalline substance, practically insoluble in water and sparingly soluble in ethanol. Tadalafil is available in the form of almond-shaped yellow, film-coated tablets at My Canadian Pharmacy.
Pharmacologic Effect
Tadalafil is a reversible, selective inhibitor of cGMP-specific PDE-5 (PDE-5 inhibitor). When sexual stimulation causes local release of nitric oxide, PDE-5 inhibition by this substance leads to the increased level of cGMP in the cavernous body of the penis. The result is a relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes a normal erection. Cialis Professional (Tadalafil) is ineffective in the absence of sexual stimulation.
In vitro studies have shown that Tadalafil is a selective PDE-5 inhibitor. PDE5 is an enzyme found in corpus cavernosum smooth muscles, smooth muscles in blood vessels of internal organs, skeletal muscles, platelets, kidneys, lungs, and cerebellum. Effects of Tadalafil on PDE5 is more active than other phosphodiesterases.
Tadalafil is 10 000 times more active in relation to PDE5 than in relation to PDE1, PDE2, PDE4, which are located in the heart, brain, blood vessels, liver and other organs. The agent blocks PDE5 10 000 times more active than PDE3 – an enzyme that is located in the heart and blood vessels. This selectivity in relation to PDE5 if compared to PDE3 is important because PDE3 is an enzyme participating in the contraction of the heart muscle. Besides, this agent is approximately 700-fold more active in relation to PDE5 than PDE6, located in the retina.
Tadalafil is also 10 000 times more active in relation to PDE-5 if compared with its effect on PDE-7 – PDE-10.
Tadalafil action lasts up to 36 hours. The effect is already obvious within 16 minutes after oral drug administration in the presence of sexual arousal.
Features of Tadalafil:
- does not cause significant changes in systolic and diastolic blood pressure compared to placebo in healthy men;
- does not cause significant changes in the heart rate;
- does not cause changes in the color recognition (blue/green) due to its low affinity for PDE-6;
- produces no marked effect on visual acuity, electroretinogram, intraocular pressure and ample size.
Specialists have revealed NO clinically significant effect on sperm characteristics in men who took daily doses of Tadalafil 6 months long.
A specific feature of this agent is a long-term effect on the body – up to 36 hours. Compare: Sildenafil (Viagra) – 6 hours, Vardenafil (Levitra) – 10 hours. The long effect of Cialis Professional allows a man to plan his sexual intercourse comfortably. This removes the emotional stress and harmonizes the relationship between partners. Tadalafil is metabolized in the liver. Withdrawal is carried out through the intestine and – in small quantities – in the urine.
Popular Canadian generics with Tadalafil active ingredient:
-
Cialis Professional; - Cialis Soft;
- Tadalafil;
- Tadadel;
- Tadalif;
- Tadasoft;
- Tadagra softgel.
Medications with Tadalafil are available in the following forms:
- Traditional pills that require some water after;
- Chewing tablets;
- Gel with a fruity taste.
