All You Need to Know about Female Viagra

Sexologists have long ago proved that sexual activity dysfunction among married couples cannot be for only a man fault. This view was widespread and well-established and hung over the consciousness of both women and men for many centuries, if not millenniums. Era and mores changed, but only men were blamed in the weakening of sexual attraction between spouses, mangling their mind and lowering their self-esteem.

Sexual disorders in women have a negative impact on the sexual life of couples. This is primarily due to their hidden nature, they do not have, as it happens at men, pronounced manifestation and for a long period of time may remain a mystery even for the woman herself. At different women, depending on the organism and personal characteristics, sexual dysfunction manifests in various degrees of explicitness and in unexpected ways.

Some women, at sexual desire and excitement presence, have no possibility to achieve orgasm, and some may not even understand and feel sexual desire. Also, there was established the dependence of women’s sexual desire from blood group. Obvious and most common factor, which indicates lack of excitement or sexual dysfunction, is the absence of lubrication in the vagina. This in its turn leads to pain during sexual intercourse for both partners. The pain only intensifies psychological impact on sexual dysfunction development.

erectile dysfunction

According to clinical statistics, 43 percent of women suffer from sexual perception dysfunction, while men – only 31 percent. Such data was published by Dr. Edward Lauman based on research, he conducted at Medical University in Chicago, USA. The main complaint of women with sexual dysfunction is lack of excitation, desire for sexual intercourse and failure to achieve orgasm. At some point of life, these problems are faced by more than third of women, according to assistant Cindy Meston, who conducts his research on sexual dysfunction impact on the sexual life of women in medical University in Austin, Texas, USA.

The principle of the effect on the female organism is similar to that which it has on men but has a dual focus. On the one hand, it increases blood flow to the genital area, and this is similar to its male equivalent action. Blood flow increases erogenous zones sensitivity located in vulvar lips area and increases libido. In addition, Viagra for women stimulates vaginal lubrication and feelings, experienced during sexual intercourse, are more vivid and intense.

Women taking this drug observe a reduced dependence on frigidity symptoms and increased erogenous zones stimulation perception. Satisfaction from sexual intimacy appears and, as a result, general psycho-emotional and physical state improve. This aspect of the action is especially valuable for elderly women, giving them chance to re-experience lost the joy of sexual activity.

Drug effectiveness is not affected by either menopause or patient’s age category. There is no habituation effect and restrictions for admission, as female Viagra does not change the hormonal balance and also does not affect sense organs perception and functioning.

History of Creation

Sildenafil, which is a basic active component, refers to a medical group «Preparations for erectile dysfunction treatment ». Originally it was created to increase blood flow in the myocardium, cardiac angina and cardiac ischemia prevention. Conducted in 1992 by American company «Pfizer» clinical trials showed that for its initial purpose, for which it was created, it does not show required efficacy, but, at the same time, shows pronounced effect on the increase in blood flow to organs located in the pelvis, in particular – genitals. Initially, studies were carried out on men, but a question arose if the impact on female genital organs can be the same.

This assumption was based on the fact that formation of male penis or female vagina at fetal occurs from one group of cells and developing process. Consequently, female body reaction on sildenafil should be similar to a reaction, which manifests in men. Clinical studies have confirmed this assumption and demonstrated that after taking the drug by women volume of blood flow directed to the clitoris and small labia increases and vulvovaginal glands begin to actively produce lubrication for vagina.

Scientific evidence of the theory about Viagra (sildenafil) influence, particularly, contained in it nitrogen dioxide, on sexual desire gave Dr. Ronald James Thompson. His presented his research after in 1998 the Nobel Prize in Science was awarded to three scientists – Robert Furchgott, Louis Ignarro and Ferid Murad, for nitrogen dioxide effect on human body discovery. Dr. Thompson conducted clinical trials in terms of medicines and means for oncological and gynecological diseases prevention. Having improved Sildenafil pharmacological formula considering adaptation to the female body and having spent six years in clinical trials of a new drug, Thompson finally got Female Viagra.

Benefits

The impact on body functioning is carried out comprehensively. On the one hand, the drug increases sexual desire and excites a woman, on the other hand, Pink Viagra increases erogenous zones sensitivity, thus in process of sexual intercourse a woman receives unforgettable experience and has the ability to reach orgasm during every sexual intercourse.

Pharmaceutical Group

Viagra refers to drug group for reproductive system functioning disorders treatment in the category of means, regulating genitourinary and reproductive systems performance efficiency, eliminating dysfunction causes. These reasons usually include:

  • low physical development;
  • physical fatigue;
  • limited nutrition;
  • hypogonadism;
  • androgen deficiency of aging male;
  • thyroid disease;
  • damage to pelvic nerves;
  • side effects of drugs of other categories;
  • mental diseases;
  • lifestyle – alcohol, drugs, smoking, active masturbation and etc.

Composition

The preparation contains two groups of components – of active and passive effect.

sexual dysfunction

Sildenafil citrate is referred – phosphodiesterase type 5 (PDE-5) inhibitor, containing nitric oxide, which has an impact on blood flow to female vulvar lips and clitoris.

Passive components are:

  • microcrystalline cellulose (cellulose microcrystallisatum), MCC – powder derived from the cotton cellulose of high purity and is intended for cleaning body at food poisoning, normalization of intestinal functions and as part of low-calorie diets;
  • titania (titanium dioxide) – a chemical agent with formula TiO2, refers to food additives (E171), improving organoleptic properties of the product, making it snow-white;
  • lactose – carbohydrate of disaccharides group with formula S12N22O11 and glucose and galactose molecules residual content, refers to a pharmacological group of excipients (fillers);
  • triacetin – food additive (E1518) with the chemical formula (CH3COO)3C3H5 with no color, no taste, which is considered as an additional source of drug energy value;
  • dicalcium phosphate anhydrous (calcium hydrophosphate) – a chemical compound of orthophosphoric acid and calcium acid salt (CaHPO4), the excipient in a pharmacological industry;
  • hypromellose magnesium – E572 emulgent, used in pharmacology to give pills and capsules desired geometric shape and help to mix substances that are poorly connected, for example, water with fat;
  • croscarmellose sodium – cellulose sodium salt, superdisintegrant, is part of pills as a substance that contributes to rapid drug disintegration and its absorption by ingestion;
  • indigo carmine aluminum lake – used in pharmacology as a colorant (E132).
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Pharmacological Effect

Female Viagra active pharmacological constituent action on the body is to increase blood circulation in pelvic organs. As a result, blood flow to female vulvar lips and clitoris increases sensitivity, sexual psycho reaction and excitability from foreplay, attraction to men also increases. After taking drug women observe increased orgasm duration and its sensuality.

It stimulates vulvovaginal glands functioning and they begin to produce vaginal lubrication in emergency mode, thus eliminating one of the pain caused during sexual intercourse – the dry vagina is not a pleasure for both man and woman.

Doctors do not recommend abusing female Viagra and take it more often than once a day and not more than one 100 mg pill. Drug begins to act 30 – 45 minutes after administration, depending on individual properties of the organism and its sensitivity to sildenafil.

Drug action duration in addition to physiological characteristics of a particular female body is affected by the psychological and emotional state of women. The drug can influence sexual attraction to men for 4 to 6 hours. The peak of sexual activity is observed on the 2nd hour after taking the pill, and after 5 hours drug action begins to slowly decline. The maximally full effect from taking such a drug arises after 3 – 4 regular administration.

Clinical Research and Medical Opinion

The clinical trials were and are constantly conducted. During these tests, its efficacy and ability to treat erectile dysfunction and restore sexual desire are investigated. Women of different nationalities, different age groups (from 19 to 85 years), various social groups and from different countries were involved to participate in these trials. During one year 550 women took part in tests, conducted by American company «Pfizer» on Dr. Thompson’s request when he worked out the new formula for sildenafil citrate.

The most important point of clinical studies was to determine side effects and their dependence on dosage, the age of studied women and their overall health.

female viagraRegardless of these parameters, virtually identical side effects were observed in all participants, namely headaches and nasal stuffiness. Less than 2% of women, who took part in drug trials, reported such health problems as abdominal pains, rash, chest pains, allergic reactions and blurred vision. Impaired vision has always been associated with dosage increase of more than 100 mg. Other side effects, which could affect clinical statistics, have not been identified.

The US also conducted clinical studies of the effect on woman’s body, who underwent surgery to remove the uterus. Age group was chosen in the range of 25 to 41 years. As stated by Dr. Berman, who led the research, in an interview with CNN, all subjects who received female Viagra, which is more than 500 people, not only reported increased sensitivity in the genital area but also in varying degrees experienced orgasms. They also observed improved general health.

MD Nachum Katlowitz, head of the laboratory of erectile dysfunction treatment methods study, in his statements about pink Viagra use claims that he «did not hesitate to prescribe Viagra for women in menopause and who experience pain during sexual intercourse due to dryness of genital organs.» The actions he explains by the fact that for women, who have passed menopause threshold, such a disorder is common. Lack of blood flow to genitals upon sexual excitation causes lubrication termination, hence dryness of female genital organs.

Dr. Irwin Goldstein, practicing in Medicine Alvarado Hospital, University of California at San Diego, California, USA conducted a clinical survey of 300 women whose sexual partners underwent erectile dysfunction treatment under his supervision. This survey results showed that almost 60% of these women during sexual intercourse experience the whole range of discomforts, from dryness of genital organs to reduced clitoris sensitivity. At the same time, sexual excitement itself requires a longer period of time to appear and there is a low probability of achieving orgasm. For these symptoms treatment Goldstein opened his own clinic in Boston, using female Viagra for treatment.

Scientists from Croatia started to develop a cream based on Viagra to combat one of the worst diseases affecting women – cellulite. At this disease, there is a change in fatty tissues, which in its turn leads to lymphatic drainage and blood flow to fat cells violation. Cellulite is very difficult to treat and Croatian doctors are hoping that enzyme inhibitors can not only break down and excrete fats but also with the help of this drug increase blood flow, whereby fat destruction and excreting will be happening more intense – such message was published in «New Scientist» magazine.

Indications

Sex therapists recommend using this drug in case of:

  • reduction or total loss of sexual desire;
  • frigidity feelings manifestations;
  • dissatisfaction after sexual intercourse;
  • insufficient lubrication to moisten vagina or its complete absence;
  • prevention and treatment of surgery on uterus or ovaries removal consequences;
  • reduction of genitals sensitivity for sexual stimulation;
  • a decrease in libido levels during a menopausal or postmenopausal period;
  • after menopause and decrease in sexual needs, etc.

In recent years, clinical trials on the effect on infertility problems have intensified. Question fairly debatable and among medical community has no consensus. However, there is an official confirmation of facts, which show that some women could get pregnant, though before that they for many years unsuccessfully treated infertility with traditional methods.

The medical literature describes in detail an incident that happened with a Kerry Horan. She married in 2002 and within 3 years made attempts to get pregnant. When she succeeded, then, to great sorrow, on the 12th week she had a miscarriage. The subsequent treatment as 3 procedures of IVF (in vitro fertilization) didn’t bring any positive results.

In Nottingham, Nottinghamshire (England), there is a private clinic that specializes in infertility prevention treatment. Horan in 2009 underwent examination in this clinic which showed that her uterus blood circulation is violated, blood flow has too small volume, so the mucous membrane is impaired, and the embryo does not receive the required amount of nutrients from the maternal blood and is not able to develop.

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The patient on doctor’s advice was prescribed a 10-day course of Viagra as a drug that increases blood circulation un internal organs, especially located in the pelvic area. After receiving this drug uterine examination showed that mucous membrane has become thicker. Horan took another course IVF and was able to give birth to a girl weighing 3700 grams in December 2009.

In Medical Center at University of Los Angeles, California, USA, research on study and development of new female infertility treatment methods are conducted under world-known urologist Jennifer Berman supervision. According to her, despite obvious differences between male and female organisms, processes that occur during sexual excitement, appear strikingly alike, accompanied by increased blood flow to genitals. In most cases of female infertility, its cause lies in circulatory disorders.

This view is shared by a doctor of psychology Laura Berman, a specialist in sexual relations area, host of TV programs about sexual health, author of many books on the subject and actress who plays herself, for example, in Discovery series: «Secrets of female sexuality» (2002). At the same time, she is an assistant professor of psychiatry and obstetrics/gynecology at Feinberg School of Medicine at Northwestern University, which is located in Evanston, Illinois, USA. She has conducted research on the effect on 200 women willing to volunteer to test the drug in a clinical setting. The results indicated not only increase in blood flow but also increased genital somatic stimulation.

Dr. Michael Sweeney, director of the medical department of pharmaceutical company «Pfizer» also does not exclude the possibility that Viagra may help women who suffer from infertility. In course of medical research in the United States, three out of four women who earlier suffered from an inability to conceive finally realized their dream.

However, we should not forget that to state that Viagra for women is indeed a means of infertility treatment or even prevention, there are too little clinical statistics. In part, it is known only that in all cases, when women after the treatment could get pregnant, they all suffered from the same problem – thin endometrium, which does not allow the embryo to sufficiently developed to be able to stay inside the uterus.

Contraindications

List of factors affecting limited use or contraindication to receiving female Viagra include:

  • allergic reaction to drugs, in particular, those for frigidity and infertility treatment;
  • reception of prescription or non-prescription drugs, without exception, herbal teas, biologically active additives or vitamin complexes;
  • upcoming surgery, not excluding dental procedures;
  • reception of nitroglycerin or drugs containing organic nitrates (they are a part of S01DA medication group), interaction with which sildenafil, contained in female Viagra, can cause a critical decrease in arterial blood pressure;
  • carried out the course of treatment of diseases connected to problems with blood supply system and pressure abnormalities, with alpha-blockers use such as terazosin (Hytrin), prazosin (Minipress) and doxazosin (Cardura), which can also be fraught with a sharp decrease in arterial blood pressure below minimal.

viagra

Its administration may be limited or even contraindicated as hazardous to health. In any case, before taking the drug, it is necessary not only to consult a doctor, preferably one that conducts a long observation of health state but also to undergo a comprehensive examination. Attending physician must necessarily be informed of Viagra reception, so that appropriate treatment actions could be taken if complications arise.

Doctors strongly do not recommend to use it, if there is such kind of general health violations as:

  • heart rhythm disorders (arrhythmia);
  • heart attack or blood stroke past during last 12 months;
  • loss of arterial blood pressure stability (hypotension or hypertension);
  • renal or hepatic diseases (metabolism destabilization);
  • sickle cell anemia (hemoglobin protein structure violation);
  • pigmented retinitis (retina degenerative disease);
  • multiple myeloma – an oncological disease characterized by a large number of malignant tumors consisting of the spinal cord and blood plasma cells);
  • leukemia – a systemic blood system disease.

In addition to these restrictions for drug admission and obligatory consultation with a specialist, you must comply with all points of medicine instruction. Statements, which may have a double meaning, are best to clarify with pharmacist or doctor.

Pharmacokinetics for Different Age Groups

In patients over 65 years of age body cleansing from sildenafil coefficient is lower in comparison with women of younger age group, and its concentration in blood plasma, thus, is higher. This excess can be up to 40% compared to the age group of 18 to 45 years old. Clinical trials have shown that frequency of adverse or undesirable effects caused by drug occurrence is not connected to patients’ age limit.

Pharmacological kinetics of female Viagra is particularly affected by the presence of severe renal insufficiency in patients. At the time when light or moderate renal function impairment at drug dosage of 50 mg did not change clearance parameters, at severe insufficiency drug intake resulted in an increase in AUC indicator (ratio of drug concentrations to output time) by 100%, and Cmax (maximal drug concentration) – by 88%. Indicators were compared with those taken from analysis of patients without renal disease.

The similar situation is observed in patients who received Viagra in presence of hepatic disease – namely cirrhosis. AUC indicator increased by 84% and Cmax – by 47%.

Dosage

To begin receiving female Viagra is necessary only after consulting a gynecologist or therapist. It is not recommended to exceed prescribed by your doctor dosage, especially at the initial stage of the treatment course.

The standard dosage for women between ages of 25 and 45 years is 100 mg. However, to start taking the drug is best with 50 mg, especially because in pharmacies female Viagra is sold in both dosages. Every woman’s body is unique and has different reactions to drugs taken. Therefore, when taking Viagra for the first time, it is desirable to determine a beginning of its operation. If the drug begins to act in the time interval from 30 to 45 minutes, therefore, the dosage of 50 mg is optimal and it is not necessary to change.

Dosage should be reduced to 25 mg in the case when the drug began to act before indicated time or increased to 100 mg when drug action manifests itself with delay. Daily dosage should not exceed 100 mg, the pill should be taken only once a day, regardless of dosage.

The drug is intended for oral administration before meal one hour before planned sexual intercourse. The drug, for better and faster absorption, can be taken with plenty of water. In properly determined dosage, the drug will have an effect on sexual desire from 4 to 6 hours.

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Dosage reduction is reasonable in cases when after drug administration kidney or liver malfunction appeared. If there appeared pain in these organs, Viagra for female must be withdrawn immediately.

For women older than 65 years daily dosage should not exceed 25 mg.

Female Viagra is strictly prohibited for children under 18 years old.

Overdose

In case of overdose, the following discomfort and side effects begin to appear:

  • dizziness;
  • headaches;
  • stomach upset;
  • rapid heartbeat (tachyarrhythmia);
  • drug-induced rhinitis (a runny nose caused by drug intake), etc.

The overdose is treated exclusively by a symptomatic method, in other words, only those symptoms have treated that manifest themselves after taking an excessive dosage of the drug. To clear the very cause of these symptoms, namely sildenafil contained in blood, by dialysis method (artificial body clearance from accumulated fluids or substances accumulated in blood vessels) is impossible because the drug itself is linked blood plasma proteins.

Drug Interactions

Doctors categorically forbid to take such drugs as:

  • erythromycin – an antibiotic belonging to macrolides class;
  • nitroglycerin – vasodilator;
  • itraconazole – an antifungal agent;
  • simetidine – antihistamine anti-ulcer medication;
  • ketoconazole – an antifungal agent;
  • isosorbide dinitrate – antianginal agent;
  • amylnitrite – vasodilator;
  • «Nitro-Dur» – a drug based on nitroglycerine, prescribed for use at cardiac angina and chronic cardiac insufficiency;
  • isosorbide mononitrate – vasodilator antianginal drugs, containing nitroglycerine.

It is not recommended to combine Viagra with substances belonging to alkyl nitrates group (also known under street name – «poppers»), potent aphrodisiac, prolonging satisfaction feeling.

Viagra is also not compatible with substances that contain beta-adrenergic blocking agents – a group of 30 drugs that are highly effective in treatment of arterial hypertension, cardiac insufficiency of various severity, ischemic heart disease (IHD) and cardiac arrhythmia (read more).

Influence on Pregnancy and Lactation

erectile dysfunction

According to Dr. Jeffrey Sher in Las Vegas, Nevada, USA, female Viagra use is not safe during pregnancy, as it increases nitric oxide content in the uterus, which adversely affects fetal development. This statement Dr. Sher made to members of American Society for Reproductive Medicine. At the same time, he claimed that he is conducting clinical trials on Viagra in the form of the vaginal suppository for infertility prevention.

Female Viagra is also not recommended during the lactation period.

Side Effects

Processing of test results in terms of side effects showed that:

  • headaches appear in 10,8% of subjects who received original drug and in 2,8% of those taking placebo;
  • blood rushes were observed at respectively 10,9% and 1,4%;
  • dizziness appears at respectively 2,9% and 1,0%;
  • impact on visual function in the form of temporary color perception disorder was observed at respectively 2,6% and 0,4% of patients;
  • changes in heart rate were fixed at 1,1% of total number of subjects;
  • genetic rhinitis (runny nose caused by taking medicine) in 2,1% of patients;
  • dyspepsia (upset digestive system with feeling heaviness in the stomach and early saturation) was detected in 3% of studied volunteers.

Female Viagra refers to medicines that are sold without a prescription, as it is considered to be a safe drug. But like any other substance, containing in its composition chemical compounds, which when entering the body cause its functional changes, Viagra has side effects. Side effects severity and time of termination in the first place depend on individual characteristics of the female body, as well as on how well the patient followed all point in instruction for use of this drug.

It should be noted that, according to clinical trials results, frequency and severity of any side effects is in any way associated with the patient’s age.

Testing the drug on human volunteers showed that when keeping to the daily dosage, patients didn’t feel worse, and side effects have usually appeared only in case of overdose.

Much depends on individual sensitivity to female Viagra basic component – sildenafil. Clinical trials, which were led by Dr. Berman in Boston clinic, member involved 500 volunteers. They were randomly divided into two equal groups, which included women of all ages. One group of subjects took Viagra pills, another group – placebo. Thus even medical personnel observing tests didn’t know which group receives placebo, and which – original drug.

The above side effects are mild and do not last long. With their long-term manifestation is necessary to go to the hospital to therapist for consultation, and in case of acute forms – call «ambulance».

Despite the fact that side effects, according to doctors, can only occur in 0,2% of women taking the drug, it is necessary to control dosage received, especially those who are predisposed to allergic reactions and diseases.

Storage Terms and Conditions

The drug should be stored in a dark place at a temperature of + 15 ° to + 30 ° C, without the possibility of children under 18 years old access to it.

Each blister pack of such pills has its expiration date or date of release. The drug over 2 years is prohibited to use.

Special Precautions for Use

It is not recommended for women to take Viagra before driving a car, motorcycle or any other vehicle for a long time. In some countries, female pilots and stewardess are not permitted for flight, if their blood contains sildenafil.

Manufacturers

In pharmaceutical market, Viagra can be purchased from several manufacturers.

  • First, from original Viagra developer, «Pfizer» – American biopharmaceutical company. Original drug brand name – «Female Viagra Original @Pfizer». The company was founded in Brooklyn, New York (North America), Long-Island, in 1849.
  • Second, from Indian company «VIPRO Lifescience» – a well-known pharmaceutical company that specializes in the production of analogs of original (branded) medicines, which according to company representatives are 100 percent copy of formulation but are released under other names. Female Viagra analog is «VIPROGRA-100» drug.
  • Third, from another Indian pharmaceutical company «Ranbaxy Laboratories Limited», although on official website this drug is not indicated, the company name appears on female Viagra packaging, sold, usually via online-pharmacy chain.
  • Fourth, packaging with an inscription «Female Viagra» can contain the name of another Indian pharmaceutical company – «Cipla Ltd», which was founded in 1965. Products list, produced by this company and posted on a website, also doesn’t have mentioning of Viagra or sildenafil content in preparations. This again points to the fact that buying medicines is best in proven regular pharmacies.