Zithromax Dosing and Administration
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Zithromax dosage may vary depending on the disease, its severity and duration. It is taken orally 1 hour before or 2 hours after meal intake once a day. Adults with infections of upper and lower respiratory tract – 125 mg / day for 1 reception for 3 days (course dose – 250 mg). When skin and soft tissue infections – the dosage is 100 mg/day for the first day – 1 reception, followed by 125 mg/day every day from 2 to 5 days (course dose – 500 mg).
In acute urinary organs infections (uncomplicated urethritis or cervicitis) – once 100 mg, Lyme disease (borreliosis) for treatment of stage I (erythema migrans) – 100 mg on the first day and 125 mg daily from 2 to 5 days (course dose – 200 g). In gastric ulcer and duodenum associated with Helicobacter pylori, – 100 mg/day for 3 days in a combination therapy for H. pylori.
Children are administered the dose of 10 mg / kg 1 time a day for three days, or the first day – 10 mg / kg, followed by 4 days – 5 -10 mg / kg / day for 3 days (a course dose – 30 mg / kg). When treating children erythema migrans dose – 20 mg/kg on the first day and 10 mg/kg, 2 to 5 days. The dosage for pneumonia – intravenous 125 mg once a day for at least 2 days later – orally 2 capsule (0.25 g); course – 7-10 days. The dosage regimen for pelvic infection – intravenous, 100 mg once, future application – in, 2 capsules (125 mg); course lasts 7 days.
Period of transition to oral intake depends on dynamics of clinical and laboratory parameters. Terms of solution for intravenous injection: 50 mg diluted with 4.8 ml water for injection and mix until complete dissolution.
My Canadian Pharmacy points out allergic reactions may be observed as a severe side effect: In rare cases, there have been reported:
- severe allergic reactions;
- anaphylactic edema;
Some of these reactions are accompanied by recurrent symptoms and require longer supervision and treatment.
Liver violations: It should be used with caution in patients with severe liver diseases. It is necessary to check liver function with symptoms appearance, such as rapid development of asthenia associated with jaundice, dark urine, bleeding tendency or hepatic encephalopathy.
Consecutive infection: as is the case with other antibiotics it is recommended to supervise symptoms of secondary infections of insensitive organisms, including fungi.
Clostridium Difficile-associated Diarrhea: diarrhea associated with Clostridium difficile, was marked at reception nearly all antibacterial agents, including Zithromax. Severity can range from mild diarrhea to severe colitis. Antibiotic therapy alters normal intestinal microflora and leads to excessive C. difficile growth.
Renal impairment: in patients with severe renal impairment take it with caution.
Elongation of myocardial repolarization and QT-interval, which carries a risk of developing cardiac arrhythmia and torsade de pointes have been reported during treatment with other macrolides. A similar effect can not completely exclude its application in patients who are at increased risk of elongated myocardial repolarization, so special care is needed in patients with:
- hereditary or documented QT-interval prolongation;
- simultaneous reception of other drugs that are directed to prolong QT-interval such as antiarrhythmics of classes IA and III, tizaprid and terfenadine;
- impaired electrolyte balance, especially in the case of hypokalemia and hypomagnesemia;
- clinically significant bradycardia, cardiac arrhythmia or severe heart failure.
It has been reported about myasthenia gravis symptoms exacerbation or myasthenic syndrome of new, in patients treated with generic Zithromax.
Streptococcal infections: Penicillin is usually the drug of choice in the treatment of pharyngitis/tonsillitis caused by Streptococcus pyogenes, and as prophylaxis of acute rheumatic fever. This drug is usually effective in acute pharyngitis treatment, but no data on effectiveness in preventing acute rheumatic fever is given.
Pregnancy and Lactation
Previous preparation experience indicates the side effects on the fetus. Notwithstanding, this drug can be administered only in cases of extreme necessity.
There is no information relating to the overdose. The overdose side effects are the temporary loss of hearing, severe nausea, vomiting and diarrhea. If you suspect an overdose, induce vomiting and immediately resort to medical care.