Advair Diskus Interactions
Advair Diskus interactions are not numerous but are necessary to be read to avoid side effects and get the maximum benefit from Advair Diskus.
When You Need to Be Careful
- Due to the risk of bronchospasm development, the patient should avoid simultaneous use of selective and non-selective beta-blockers except the case when they are essential to the patient.
- In normal situations, Advair Diskus (mainly Fluticasone active substance) inhalation is characterized by its low concentrations in plasma due to an intensive metabolism in the “first” pass and high systemic clearance under the influence of CYP3A4 in the gut and liver. These clinically relevant interactions involving Fluticasone are very rare.
- The researches on the topic of interactions has shown that Ritonavir (a highly active inhibitor of CYP3A4) may cause a sharp increase in the concentration of Fluticasone in plasma, resulting in significantly reduced serum cortisol concentrations.
- There are reports of clinically significant Advair Diskus interactions in patients who received both Advair and Ritonavir. These interactions cause side effects such as Cushing’s syndrome and adrenal suppression. Therefore, you should avoid simultaneous use of Fluticasone and Ritonavir, unless the potential benefit to the patient outweighs the risk of systemic Advair Diskus side effects.
- Other inhibitors of CYP3A4 produce negligible (erythromycin) and minor (ketoconazole) increased the content of Fluticasone in plasma when there is no decrease in serum cortisol concentrations. Despite this, it is recommended to be careful while applying Advair Diskus (Fluticasone / Salmeterol) and potent inhibitors of CYP3A4 (e.g. ketoconazole), as such combinations do not exclude the probability of increasing the concentration of Fluticasone in plasma.
- Xanthine derivatives, corticosteroids and diuretics increase the risk of hypokalemia (especially in patients with acute exacerbation of bronchial asthma and during hypoxia).
- MAO inhibitors and tricyclic antidepressants increase the risk of Canadian Advair Diskus side effects from the CCC.
* Advair Diskus is compatible with Cromoglicic acid.
Consult the doctor before Advair Diskus usage!