Advair Diskus Side Effects

Advair Diskus side effects may occur due to Salmeterol and Fluticasone interactions and tolerance by the body. There is no evidence that the simultaneous administration of Salmeterol and Fluticasone – Advair Diskus active substances – can cause additional side effects.
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The substances may cause paradoxical bronchospasm. In this case, you should immediately apply a short-term inhaled bronchodilator, cancel the therapy and start an alternative therapy under the doctor’s advice.

My Canadian Pharmacy has selected the most frequent Advair Disk side effects (two groups caused by Salmeterol or Fluticasone).

Salmeterol side effects

The most typical pharmacological side effects of the beta2-adrenergic agonist contained in Advair Diskus for asthma:

  • Tremor;
  • heart palpitations;
  • headache;
  • hypokalemia.

They tend to be transient and diminish with continued therapy with Salmeterol.

Sensitive patients may also experience arrhythmias (including atrial fibrillation, supraventricular tachycardia and extrasystoles).

There have been rare reports of arthralgia, nervousness, abdominal pain, nausea, vomiting and hypersensitivity reactions, including skin rash, peripheral edema and angioedema, irritation of the oropharynx mucous membranes, changes in sense of taste (dysgeusia) after Advair Diskus usage.

There are unique reports of painful muscle spasms and cases of hyperglycemia.
advair side effects

Fluticasone Side Effects

My Canadian Pharmacy professional team points out the most frequent Fluticasone side effetcts:

  • Rough or throaty voice;
  • candidiasis (thrush) of the mouth and pharynx;
  • hypersensitivity reactions in the form of cutaneous edema.

There were also reports of hypersensitivity reactions manifested as angioedema (mainly facial swelling and oropharynx), respiratory disorders (mainly shortness of breath and / or bronchospasm) and anaphylactic reactions.

caution!The severity and frequency of rough or throaty voice can be minimized by rinsing the mouth with water after Advair Diskus inhalation. Symptomatic candidiasis can be treated with topical antifungal drugs, continuied Fluticasone therapy.

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There were rare reports of anxiety, sleep disorders and behavioral disorders, including hyperactivity and irritability (predominantly in children); hyperglycemia.

Theoretically, there are some other possible Advair Diskus side effects: Cushing’s symptoms or Cushingoid syndrome, adrenal suppression, growth retardation in children and adolescents, decrease in bone mineral density, cataract and glaucoma.

With prolonged exceeded Advair Diskus dosages (Salmeterol with Fluticasone combination), patients may develop a significant inhibition of the adrenal cortex function. There are very rare reports of acute adrenal crisis, which occurred mostly in children treated with higher doses of generic Advair (several months or years); symptoms of adrenal crisis include hypoglycemia, accompanied by the reduced the level of consciousness and / or convulsions.

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